Gupta and Schupbach, 2003, Development 130(24): 6075--6087

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Gupta and Schupbach, 2003, Development 130(24): 6075--6087
FlyBase Identifier Has FlyBase identifier::FBrf0167510
FlyBase URL Has FlyBase URL::http://flybase.org/reports/FBrf0167510.html
Publication Type Is publication type::paper
Publication Year Was published in year::2003
PubMed ID Has PubMed ID::14597574
PubMed URL Has PubMed URL::http://www.ncbi.nlm.nih.gov/pubmed/14597574

Title

Has title::Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis.

Abstract

[[Has PubMed abstract::Patterning of the Drosophila egg requires cooperation between the germline cells and surrounding somatic follicle cells. In order to identify genes involved in follicle cell patterning, we analyzed enhancer trap lines expressed in specific subsets of follicle cells. Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize phosphatidylcholine. Drosophila Cct1 is expressed at high levels in three specific subsets of follicle cells, and this expression is regulated, at least in part, by the TGF-beta and Egfr signaling pathways. Mutations in Cct1 result in a number of defects, including a loss of germline stem cell maintenance, mispositioning of the oocyte, and a shortened operculum, suggesting that Cct1 plays multiple roles during oogenesis. In addition, Cct1 mutants display a novel branched ovariole phenotype, demonstrating a requirement for this gene during ovarian morphogenesis. These data provide the first evidence for a specific role for CCT, and thus for phosphatidylcholine, in patterning during development.]]

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