|Name||Has current name::Dorsal-related immunity factor|
|Species||Has genus::Drosophila Has species::melanogaster|
|Annotation symbol||Has current annotation symbol::CG6794|
|FlyBase ID||Has FlyBase identifier::FBgn0011274|
The gene Dorsal-related immunity factor is referred to in FlyBase by the symbol Dmel\Dif (CG6794, FBgn0011274). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; protein binding; sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; DNA binding. There is experimental evidence for 11 unique biological process terms, many of which group under: biological regulation; response to stress; single-organism developmental process; immune system process; defense response to fungus; cellular process; response to other organism; response to stimulus; response to DNA damage stimulus; immune response; larval lymph gland hemocyte differentiation; positive regulation of biological process; gland morphogenesis; defense response to bacterium; system development. 35 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; dorsocentral bristle; mesothoracic tergum. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Cell surface receptor IPT/TIG; Dorsal protein; Immunoglobulin E-set; Immunoglobulin-like fold; NF-kappa-B/Rel/Dorsal; Rel homology domain; p53-like transcription factor, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1633246_s_at partially aligns to an exonic region of only a subset of 3 of the 4 FlyBase-annotated transcript isoforms of Dif: 3 out of 14 probes fall into this exonic region. Gene sequence location is 2L:17413248..17433161.