Methot and Basler, 2000, Development 127(18): 4001--4010

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Methot and Basler, 2000, Development 127(18): 4001--4010
FlyBase Identifier Has FlyBase identifier::FBrf0132087
FlyBase URL Has FlyBase URL::http://flybase.org/reports/FBrf0132087.html
Publication Type Is publication type::paper
Publication Year Was published in year::2000
PubMed ID Has PubMed ID::10952898
PubMed URL Has PubMed URL::http://www.ncbi.nlm.nih.gov/pubmed/10952898

Title

Has title::Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

Abstract

[[Has PubMed abstract::Hedgehog controls the expression of key developmental genes through the conversion of the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (Ci[rep]) form. Proteolytic cleavage of full-length Ci is important for the generation of Ci[rep], but little is known about how Ci[act] arises in response to Hh. Here we examine Hh signal transduction components for their role in the conversion of full-length Ci into either Ci[act] or Ci[rep]. We report that Cos2, PKA and Fused are necessary for the generation of Ci[rep], whereas the inhibition of either Cos2 or PKA activity is a prerequisite for Ci[act] formation. Fused (Fu) kinase stimulates a constitutively active form of Ci in a Hh-dependent manner, suggesting that Fu enhances the activity rather than the formation of Ci[act]. Su(fu) reduces the nuclear accumulation of the constitutively active form of Ci, arguing that Su(fu) can function subsequent to Ci[act] formation. We propose that Hh induces target gene expression by a two-step mechanism in which Ci[act] is first formed and then accumulates in the nucleus via Fu-induced neutralization of Su(fu) activity.]]

Genes from Reference

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