FlyBase:Signaling Pathway Report

Last Updated: 15 June 2018

The ‘Gene Group - Pathway Report’ is a sub-category of our Gene Group resource, which houses functional collections of genes such as complexes and gene families. ‘Pathway Reports’ list genes that have been experimentally shown to act within a pathway or to regulate a pathway. The reports are tailored to display information that may be useful to understanding the role of a particular pathway component or regulator: membership of other Gene Groups, experimentally characterized molecular functions and supporting research papers. Useful links to external resources and publications are provided, as well as options for export and orthology tools.

The ‘Pathway Report’ pages are a prelude to what will become a rich resource for researchers to access the curated data on pathway members and regulators. Our first aim is to make the list of curated pathway genes available for immediate use and review. Over 2018, we will add more pathways based on a first-pass review of the research literature. We welcome any feedback <http://flybase.org/contact/email> to help improve the usefulness and accuracy of these gene lists.

All Gene Group Pathways in FlyBase are compiled manually by FlyBase curators, based on research literature, using standards for inclusion agreed by the Gene Ontology consortium. The number of research papers that have been used as evidence for membership gene is shown in the Members table. These references can be viewed as a hitlist by clicking on the number. The number of pathway references associated with a gene may also help researchers weigh the evidence behind its inclusion. All source references are given in full at the foot of the page.

Buttons are provided to export these member genes to our ‘Batch Download’ tool, if you wish to download associated data (phenotypes, expression data, protein interactions etc.), or to a standard FlyBase HitList, if you want to further refine or analyse the gene list, or to our ortholog tool, DIOPT, to obtain a list of predicted orthologs.

General Information

Name	The FlyBase full name for the Gene Group.
Symbol	The FlyBase symbol for the Gene Group.
Date last reviewed	Date that the group was created or last reviewed, in format 'YEAR-MONTH-DAY'.
Species	The species for which the Gene Group has been compiled.
FlyBase ID	The unique identifier for the FlyBase Gene Group (FBgg number).
Number of members	The number of genes in the Gene Group.

Description

Description	A short textual description of the group, written by FlyBase curators based on the given reference(s). References are hyperlinked to their respective Reference Report in FlyBase or to PubMed.
Notes and selected reviews	May include selected publications for background information, describe the criteria used for inclusion/exclusion or any notes to aid interpretation of pathway membership.
Biological Process Gene Ontology (GO) term(s)	Term(s) from the Biological Process branch of the Gene Ontology that are most relevant to the Gene Group, hyperlinked to the respective FlyBase 'Term Report'. This term, or a child of it, is used to annotate all member genes.

Related Gene Groups

Parent group(s)	Any immediate parent super-groups within FlyBase are shown here, hyperlinked to their respective Report.
Component group(s)	Any immediate child sub-groups within FlyBase are shown here, hyperlinked to their respective Report.
Other related group(s)	Any non-protein complex groups within FlyBase that are related to the current Pathway but not through a parent-child relationship (e.g. ligands-receptors, enzymes-substrates) are shown here, hyperlinked to their respective Gene Group Report.
Protein Complex group(s)	Any protein complex groups within FlyBase that act in the current Pathway but not through a parent-child relationship are shown here, hyperlinked to their respective Gene Group Report.

Members

The Members table lists all member genes of the current Gene Group and any subgroups - subgroups are partitioned into individual subsections, the title bar of which is hyperlinked to the Gene Group Report for that subgroup. Member genes are listed alphabetically within each subsection

For all members

View Orthologs	Runs the list of genes through the QuickSearch Orthologs tool, and displays a list of orthologs from human and several different model organisms.
Export to HitList	Export all genes in the Members Table to a standard FlyBase HitList, which allows further refinement and analysis of the gene list.
Export to Batch Download	Export all genes in the Members Table to the FlyBase 'Batch Download' tool, which allows bulk download of any associated data fields.

Members Table

Gene Symbol	The FlyBase symbol for the gene, hyperlinked to the Gene Report for that gene.
Gene Name	The FlyBase full name for the gene.
Also Known As	A list of up to five commonly used symbol synonyms for the gene. (This list is made computationally, based on the frequency of alternative symbols that have been curated from the literature.)
Source Material for Membership	The reference(s) that state a specific gene is a member of this particular Gene Group, hyperlinked to the Reference Report for that reference.

External Data

Equivalent Group(s)	The name and source of any equivalent Gene Group pages for other organisms such as humans (HUGO Gene Nomenclature Committee, HGNC), nematodes (WormBase) or Arabidopsis (The Arabidopsis Information Resource, TAIR), hyperlinked to that particular resource.
Other resource(s)	The name of any other specialist websites relevant to the Gene Group, hyperlinked to that resource.

Synonyms and Secondary IDs

Synonyms(s)	Alternative commonly used symbols/names used in Drosophila literature and/or the wider field to refer the Gene Group.
Secondary FlyBase ID(s)	Any non-current FlyBase Gene Group ID(s) (FBgg numbers) that have been used previously to refer to the Gene Group but which have retired for some reason (e.g. a new FBgg number is assigned if two or more Gene Groups are merged, or if a single Gene Group is split into separate groups).

References

The full citations of all references used to compile the group, organised by publication type, and hyperlinked to their respective Reference Reports.